Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression.

Lin, Lin; Holmes, Benjamin; Shen, Max W; Kammeron, Darnell; Geijsen, Niels; Gifford, David K; Sherwood, Richard I

Lin, Lin; Holmes, Benjamin; Shen, Max W; Kammeron, Darnell; Geijsen, Niels; Gifford, David K; Sherwood, Richard I.

Afiliação

Lin L; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht 3584 CT, the Netherlands.
Holmes B; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shen MW; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kammeron D; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht 3584 CT, the Netherlands.
Geijsen N; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht 3584 CT, the Netherlands; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands. Electronic address: n.geijsen@lumc.nl.
Gifford DK; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Electrical Engineering and Computer Science, Massachusetts In
Sherwood RI; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht 3584 CT, the Netherlands. Electronic address: rsherwood@rics.bwh.harvard.edu.

Cell Rep ; 33(8): 108426, 2020 11 24.

Article em En | MEDLINE | ID: mdl-33238122

Assuntos

Expressão Gênica/genética; Redes Reguladoras de Genes/genética; Oncogenes/imunologia; Humanos; Transdução de Sinais

Palavras-chave

AP-1 signaling; CRISPR-Cas9 screening; NF-κB signaling; cytidine deaminase; in-cis and in-trans regulation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Expressão Gênica / Redes Reguladoras de Genes Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google