Radiosensitizing effects of citrate-coated cobalt and nickel ferrite nanoparticles on breast cancer cells.
Nanomedicine (Lond)
; 15(29): 2823-2836, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33241971
ABSTRACT
Aim:
Evaluation of the biocompatibility and radiosensitizer potential of citrate-coated cobalt (cit-CF) and nickel (cit-NF) ferrite nanoparticles (NPs). Materials &methods:
Normal fibroblast and breast cancer cells were treated with different concentrations of citrate-coated ferrite NPs (cit-NPs) and irradiated with a cobalt-60 source at doses of 1 and 3 Gy. After 24 h, cell metabolism, morphology alterations and nanoparticle uptake were evaluated.Results:
Cit-CF and cit-NF NPs showed no toxicity to normal cells up to 250 and 100 µg.ml-1, respectively. Combination of cit-NP and ionizing radiation resulted in up to fivefold increase in the radiation therapeutic efficacy against breast cancer cells.Conclusion:
Cit-CF and cit-NF NPs are suitable candidates for application as breast cancer cell radiosensitizers.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radiossensibilizantes
/
Neoplasias da Mama
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Nanopartículas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article