The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology.

Gleeson, John P; Fein, Katherine C; Chaudhary, Namit; Doerfler, Rose; Newby, Alexandra N; Whitehead, Kathryn A

Gleeson, John P; Fein, Katherine C; Chaudhary, Namit; Doerfler, Rose; Newby, Alexandra N; Whitehead, Kathryn A.

Afiliação

Gleeson JP; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Fein KC; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Chaudhary N; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Doerfler R; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Newby AN; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Whitehead KA; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States. Electronic address: kawhite@cmu.edu.

Int J Pharm ; 593: 120120, 2021 Jan 25.

Article em En | MEDLINE | ID: mdl-33249250

Assuntos

Mucosa Intestinal; Intestino Delgado; Administração Oral; Animais; Humanos; Absorção Intestinal; Mucosa Intestinal/metabolismo; Camundongos; Peptídeos/metabolismo; Permeabilidade; Tecnologia

Palavras-chave

Intestinal permeability; Oral drug delivery; Pediatric therapy; Protein delivery; Tight junctions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mucosa Intestinal / Intestino Delgado Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mucosa Intestinal / Intestino Delgado Idioma: En Ano de publicação: 2021 Tipo de documento: Article