Down-regulation of dual-specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2.

Kanda, Yuki; Mizuno, Ayami; Takasaki, Teruaki; Satoh, Ryosuke; Hagihara, Kanako; Masuko, Takashi; Endo, Yuichi; Tanabe, Genzoh; Sugiura, Reiko

Kanda, Yuki; Mizuno, Ayami; Takasaki, Teruaki; Satoh, Ryosuke; Hagihara, Kanako; Masuko, Takashi; Endo, Yuichi; Tanabe, Genzoh; Sugiura, Reiko.

Afiliação

Kanda Y; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Mizuno A; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Takasaki T; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Satoh R; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Hagihara K; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Masuko T; Laboratory of Natural Drug Resources, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Endo Y; Laboratory of Natural Drug Resources, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.
Tanabe G; Laboratory of Organic Chemistry, Department of Pharmacy, Kindai University, Higashi-Osaka, Japan.
Sugiura R; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan.

Genes Cells ; 26(2): 109-116, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33249692

Assuntos

Apoptose/efeitos dos fármacos; Álcoois Benzílicos/farmacologia; Regulação para Baixo/genética; Fosfatase 6 de Especificidade Dupla/genética; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Receptor ErbB-2/metabolismo; Animais; Apoptose/genética; Proliferação de Células/efeitos dos fármacos; Regulação para Baixo/efeitos dos fármacos; Fosfatase 6 de Especificidade Dupla/metabolismo; Camundongos; Células NIH 3T3; Oncogenes

Palavras-chave

ACA-28; ERK MAPK; apoptosis; cancer treatment; dual-specificity phosphatase; proteasome-dependent degradation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Álcoois Benzílicos / Regulação para Baixo / Apoptose / Receptor ErbB-2 / Sistema de Sinalização das MAP Quinases / Fosfatase 6 de Especificidade Dupla Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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