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Characterization of the Stereoselective P450 Enzyme BotCYP Enables the In Vitro Biosynthesis of the Bottromycin Core Scaffold.
Adam, Sebastian; Franz, Laura; Milhim, Mohammed; Bernhardt, Rita; Kalinina, Olga V; Koehnke, Jesko.
Afiliação
  • Adam S; Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus Geb. E8.1, 66123 Saarbrücken, Germany.
  • Franz L; Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus Geb. E8.1, 66123 Saarbrücken, Germany.
  • Milhim M; Department of Biochemistry, Saarland University, Campus Geb. B2.2, 66123 Saarbrücken, Germany.
  • Bernhardt R; Department of Biochemistry, Saarland University, Campus Geb. B2.2, 66123 Saarbrücken, Germany.
  • Kalinina OV; Research Group Drug Bioinformatics, HIPS, HZI, 66123 Saarbrücken, Germany.
  • Koehnke J; Faculty of Medicine, Saarland University, 66424 Homburg, Germany.
J Am Chem Soc ; 142(49): 20560-20565, 2020 12 09.
Article em En | MEDLINE | ID: mdl-33249843
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 Idioma: En Ano de publicação: 2020 Tipo de documento: Article