Reduced All-Cause Mortality in the ETHOS Trial of Budesonide/Glycopyrrolate/Formoterol for Chronic Obstructive Pulmonary Disease. A Randomized, Double-Blind, Multicenter, Parallel-Group Study.

Martinez, Fernando J; Rabe, Klaus F; Ferguson, Gary T; Wedzicha, Jadwiga A; Singh, Dave; Wang, Chen; Rossman, Kimberly; St Rose, Earl; Trivedi, Roopa; Ballal, Shaila; Darken, Patrick; Aurivillius, Magnus; Reisner, Colin; Dorinsky, Paul

Martinez, Fernando J; Rabe, Klaus F; Ferguson, Gary T; Wedzicha, Jadwiga A; Singh, Dave; Wang, Chen; Rossman, Kimberly; St Rose, Earl; Trivedi, Roopa; Ballal, Shaila; Darken, Patrick; Aurivillius, Magnus; Reisner, Colin; Dorinsky, Paul.

Afiliação

Martinez FJ; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
Rabe KF; LungenClinic Grosshansdorf and Christian-Albrechts University Kiel, Airway Research Center North, Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.
Ferguson GT; Pulmonary Research Institute of Southeast Michigan, Farmington Hills, Michigan.
Wedzicha JA; National Heart and Lung Institute, London, United Kingdom.
Singh D; Medicines Evaluation Unit, University of Manchester, Manchester University NHS Foundation Hospitals Trust, Manchester, United Kingdom.
Wang C; National Clinical Research Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
Rossman K; AstraZeneca, Morristown, New Jersey.
St Rose E; AstraZeneca, Morristown, New Jersey.
Trivedi R; AstraZeneca, Durham, North Carolina.
Ballal S; AstraZeneca, Morristown, New Jersey.
Darken P; AstraZeneca, Wilmington, Delaware; and.
Aurivillius M; AstraZeneca, Gothenburg, Sweden.
Reisner C; AstraZeneca, Morristown, New Jersey.
Dorinsky P; AstraZeneca, Durham, North Carolina.

Am J Respir Crit Care Med ; 203(5): 553-564, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33252985

Assuntos

Broncodilatadores/uso terapêutico; Budesonida/uso terapêutico; Fumarato de Formoterol/uso terapêutico; Glucocorticoides/uso terapêutico; Glicopirrolato/uso terapêutico; Mortalidade; Antagonistas Muscarínicos/uso terapêutico; Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico; Idoso; Causas de Morte; Método Duplo-Cego; Quimioterapia Combinada; Feminino; Volume Expiratório Forçado; Humanos; Estimativa de Kaplan-Meier; Masculino; Pessoa de Meia-Idade; Modelos de Riscos Proporcionais; Doença Pulmonar Obstrutiva Crônica/fisiopatologia; Índice de Gravidade de Doença

Palavras-chave

BGF metered-dose inhaler; chronic obstructive pulmonary disease; inhaled corticosteroids/long-acting muscarinic antagonist/long-acting ß2-agonist; mortality; triple therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Broncodilatadores / Mortalidade / Antagonistas Muscarínicos / Budesonida / Doença Pulmonar Obstrutiva Crônica / Fumarato de Formoterol / Glucocorticoides / Glicopirrolato Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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