Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides.
Molecules
; 25(23)2020 Nov 24.
Article
em En
| MEDLINE
| ID: mdl-33255230
ABSTRACT
Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives the assembly into ß-sheet structures with hydrogen-bonded guanosine forming additional secondary structures cooperatively within the peptide framework. Interestingly, the distinct supramolecular morphologies are driven not by metal cation responsiveness common to guanine-based materials, but by the C-terminal peptide chemistry. This work highlights the structural diversity of self-assembling nucleopeptides and will help advance the development of applications for these supramolecular guanosine-containing nucleopeptides.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Ácidos Nucleicos Peptídicos
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Guanosina
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article