Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma.

Kiyokawa, Juri; Kawamura, Yoichiro; Ghouse, Shanawaz M; Acar, Simge; Barçin, Erinç; Martínez-Quintanilla, Jordi; Martuza, Robert L; Alemany, Ramon; Rabkin, Samuel D; Shah, Khalid; Wakimoto, Hiroaki

Kiyokawa, Juri; Kawamura, Yoichiro; Ghouse, Shanawaz M; Acar, Simge; Barçin, Erinç; Martínez-Quintanilla, Jordi; Martuza, Robert L; Alemany, Ramon; Rabkin, Samuel D; Shah, Khalid; Wakimoto, Hiroaki.

Afiliação

Kiyokawa J; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Kawamura Y; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Ghouse SM; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Acar S; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Barçin E; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Martínez-Quintanilla J; Stem Cells and Cancer Laboratory, Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Martuza RL; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Alemany R; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Rabkin SD; ProCure Program, Catalan Institute of Oncology - ICO and Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Shah K; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Wakimoto H; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.

Clin Cancer Res ; 27(3): 889-902, 2021 02 01.

Article em En | MEDLINE | ID: mdl-33257429

Assuntos

Neoplasias Encefálicas/terapia; Glioblastoma/terapia; Hialuronoglucosaminidase/genética; Inibidores de Checkpoint Imunológico/administração & dosagem; Terapia Viral Oncolítica/métodos; Adenoviridae/genética; Adenoviridae/imunologia; Animais; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/imunologia; Neoplasias Encefálicas/patologia; Linhagem Celular Tumoral; Modelos Animais de Doenças; Matriz Extracelular/efeitos dos fármacos; Matriz Extracelular/imunologia; Matriz Extracelular/metabolismo; Feminino; Glioblastoma/genética; Glioblastoma/imunologia; Glioblastoma/patologia; Humanos; Ácido Hialurônico/metabolismo; Hialuronoglucosaminidase/metabolismo; Imunoterapia/métodos; Camundongos; Vírus Oncolíticos/genética; Vírus Oncolíticos/imunologia; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Microambiente Tumoral/efeitos dos fármacos; Microambiente Tumoral/genética; Microambiente Tumoral/imunologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Terapia Viral Oncolítica / Inibidores de Checkpoint Imunológico / Hialuronoglucosaminidase Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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