Development of ß-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase II&#945; inhibition and apoptosis induction.

Tokala, Ramya; Mahajan, Surbhi; Kiranmai, Gaddam; Sigalapalli, Dilep Kumar; Sana, Sravani; John, Stephy Elza; Nagesh, Narayana; Shankaraiah, Nagula

Development of ß-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis induction.

Tokala, Ramya; Mahajan, Surbhi; Kiranmai, Gaddam; Sigalapalli, Dilep Kumar; Sana, Sravani; John, Stephy Elza; Nagesh, Narayana; Shankaraiah, Nagula.

Afiliação

Tokala R; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Mahajan S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Kiranmai G; CSIR-Centre for Cellular and Molecular Biology, Medical Biotechnology Complex, ANNEXE II, Uppal Road, Hyderabad 500007, India.
Sigalapalli DK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Sana S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
John SE; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Nagesh N; CSIR-Centre for Cellular and Molecular Biology, Medical Biotechnology Complex, ANNEXE II, Uppal Road, Hyderabad 500007, India. Electronic address: nagesh@ccmb.res.in.
Shankaraiah N; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India. Electronic address: shankar@niperhyd.ac.in.

Bioorg Chem ; 106: 104481, 2021 01.

Article em En | MEDLINE | ID: mdl-33261848

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Benzotiazóis/farmacologia; Carbolinas/farmacologia; DNA Topoisomerases Tipo II/metabolismo; Desenvolvimento de Medicamentos; Inibidores da Topoisomerase II/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Benzotiazóis/química; Carbolinas/química; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade; Inibidores da Topoisomerase II/síntese química; Inibidores da Topoisomerase II/química

Palavras-chave

Benzothiazole; Cytotoxicity; DNA binding; Dissociation constant; Flow cytometry; Topo IIα inhibition; ß-Carboline

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbolinas / Apoptose / DNA Topoisomerases Tipo II / Benzotiazóis / Inibidores da Topoisomerase II / Desenvolvimento de Medicamentos / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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