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CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin.
Keir, Holly R; Richardson, Hollian; Fillmore, Christina; Shoemark, Amelia; Lazaar, Aili L; Miller, Bruce E; Tal-Singer, Ruth; Chalmers, James D; Mohan, Divya.
Afiliação
  • Keir HR; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK.
  • Richardson H; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK.
  • Fillmore C; GSK R&D, Stevenage, UK.
  • Shoemark A; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK.
  • Lazaar AL; GSK R&D, Collegeville, PA, USA.
  • Miller BE; GSK R&D, Collegeville, PA, USA.
  • Tal-Singer R; GSK R&D, Collegeville, PA, USA.
  • Chalmers JD; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK.
  • Mohan D; GSK R&D, Collegeville, PA, USA.
ERJ Open Res ; 6(4)2020 Oct.
Article em En | MEDLINE | ID: mdl-33263062
ABSTRACT
The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https//bit.ly/32SeisO.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article