Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings.
Eur J Histochem
; 64(4)2020 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-33272008
ABSTRACT
A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-ß), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-ß release at the lesion site. TGF-ß recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ossificação Heterotópica
/
Hiperostose Esquelética Difusa Idiopática
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article