Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment.

Nehal, Nida; Nabi, Bushra; Rehman, Saleha; Pathak, Ankita; Iqubal, Ashif; Khan, Saif Ahmad; Yar, M Shahar; Parvez, Suhel; Baboota, Sanjula; Ali, Javed

Nehal, Nida; Nabi, Bushra; Rehman, Saleha; Pathak, Ankita; Iqubal, Ashif; Khan, Saif Ahmad; Yar, M Shahar; Parvez, Suhel; Baboota, Sanjula; Ali, Javed.

Afiliação

Nehal N; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Nabi B; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Rehman S; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Pathak A; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Iqubal A; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Khan SA; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Yar MS; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Parvez S; Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Baboota S; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Ali J; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address: jali@jamiahamdard.ac.in.

Int J Biol Macromol ; 167: 605-619, 2021 Jan 15.

Article em En | MEDLINE | ID: mdl-33278450

Assuntos

Quitosana/química; Indóis/administração & dosagem; NF-kappa B/metabolismo; Nigella/química; Doença de Parkinson/metabolismo; Óleos de Plantas/administração & dosagem; Fator de Necrose Tumoral alfa/metabolismo; Animais; Benzoquinonas/farmacologia; Modelos Animais de Doenças; Estabilidade de Medicamentos; Sinergismo Farmacológico; Emulsões; Feminino; Humanos; Indóis/química; Indóis/farmacocinética; Masculino; Simulação de Acoplamento Molecular; NF-kappa B/química; Nanopartículas; Oxidopamina/efeitos adversos; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/etiologia; Óleos de Plantas/química; Óleos de Plantas/farmacocinética; Ratos; Fator de Necrose Tumoral alfa/química

Palavras-chave

Mucoadhesion; Nanoemulsion; Neuroinflammation; Oxidative stress; Parkinson's disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Óleos de Plantas / NF-kappa B / Fator de Necrose Tumoral alfa / Nigella / Quitosana / Indóis Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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