The optimal therapeutic irisin dose intervention in animal model: A systematic review.

Alzoughool, Foad; Al-Zghoul, Mohammad Borhan; Al-Nassan, Saad; Alanagreh, Lo'ai; Mufleh, Dana; Atoum, Manar

Alzoughool, Foad; Al-Zghoul, Mohammad Borhan; Al-Nassan, Saad; Alanagreh, Lo'ai; Mufleh, Dana; Atoum, Manar.

Afiliação

Alzoughool F; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Al-Zghoul MB; Basic Veterinary Sciences, School of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Al-Nassan S; Department of Physical and Occupational Therapy, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Alanagreh L; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Mufleh D; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Atoum M; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.

Vet World ; 13(10): 2191-2196, 2020 Oct.

Article em En | MEDLINE | ID: mdl-33281355

ABSTRACT

ABSTRACT

BACKGROUND AND

AIM:

Irisin, a novel myocyte-secreted hormone, was proposed to mediate some of the beneficial effects of exercise such as browning of adipocytes, thermogenesis, and metabolic homeostasis. Recently, several animals' models' studies have been performed to investigate the therapeutic impact of irisin in several disorders. Several interventional trials used different doses. However, optimum dose was not determined. This systematic review aims to identify the optimal dose of interventional irisin in mice and rat animal models. MATERIALS AND

METHODS:

Online databases PubMed, Google Scholar, and Springer were systematically searched from 2012 to 2019. The words searched were irisin, irisin and animal model, physical activity, and irisin and irisin dosage. Non-irisin doses, in vitro studies, and factors influencing irisin levels were excluded.