SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic <i>ß</i>-Cells and in the Human Pancreas Microvasculature.

Fignani, Daniela; Licata, Giada; Brusco, Noemi; Nigi, Laura; Grieco, Giuseppina E; Marselli, Lorella; Overbergh, Lut; Gysemans, Conny; Colli, Maikel L; Marchetti, Piero; Mathieu, Chantal; Eizirik, Decio L; Sebastiani, Guido; Dotta, Francesco

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic ß-Cells and in the Human Pancreas Microvasculature.

Fignani, Daniela; Licata, Giada; Brusco, Noemi; Nigi, Laura; Grieco, Giuseppina E; Marselli, Lorella; Overbergh, Lut; Gysemans, Conny; Colli, Maikel L; Marchetti, Piero; Mathieu, Chantal; Eizirik, Decio L; Sebastiani, Guido; Dotta, Francesco.

Afiliação

Fignani D; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Licata G; Fondazione Umberto Di Mario, c/o Toscana Life Sciences, Siena, Italy.
Brusco N; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Nigi L; Fondazione Umberto Di Mario, c/o Toscana Life Sciences, Siena, Italy.
Grieco GE; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Marselli L; Fondazione Umberto Di Mario, c/o Toscana Life Sciences, Siena, Italy.
Overbergh L; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Gysemans C; Fondazione Umberto Di Mario, c/o Toscana Life Sciences, Siena, Italy.
Colli ML; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Marchetti P; Fondazione Umberto Di Mario, c/o Toscana Life Sciences, Siena, Italy.
Mathieu C; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Eizirik DL; Clinical and Experimental Endocrinology (CEE), Katholieke Universiteit Leuven (KULEUVEN), Leuven, Belgium.
Sebastiani G; Clinical and Experimental Endocrinology (CEE), Katholieke Universiteit Leuven (KULEUVEN), Leuven, Belgium.
Dotta F; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.

Front Endocrinol (Lausanne) ; 11: 596898, 2020.

Article em En | MEDLINE | ID: mdl-33281748

Assuntos

Enzima de Conversão de Angiotensina 2/metabolismo; COVID-19/virologia; Células Secretoras de Insulina/metabolismo; Microvasos/metabolismo; Pâncreas/metabolismo; SARS-CoV-2/isolamento & purificação; COVID-19/metabolismo; COVID-19/patologia; Células Cultivadas; Citocinas/metabolismo; Humanos; Células Secretoras de Insulina/virologia; Microvasos/virologia; Pâncreas/virologia

Palavras-chave

COVID-19; SARS-CoV-2; angiotensin I-converting enzyme type 2 (ACE2); beta-cell; diabetes; human pancreatic islets; inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pâncreas / Células Secretoras de Insulina / Microvasos / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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