Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery.
Chem Commun (Camb)
; 57(1): 109-112, 2021 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-33290458
ABSTRACT
Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfatase Alcalina
/
Esterases
/
Lipídeos
/
Lipossomos
/
Lisossomos
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Manosefosfatos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article