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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Nguyen, Nga T; Du, Kuo; Akakpo, Jephte Y; Umbaugh, David S; Jaeschke, Hartmut; Ramachandran, Anup.
Afiliação
  • Nguyen NT; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
  • Du K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
  • Akakpo JY; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
  • Umbaugh DS; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
  • Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
  • Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address: aramachandran@kumc.edu.
Toxicol Lett ; 338: 21-31, 2021 Mar 01.
Article em En | MEDLINE | ID: mdl-33290831
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mitocôndrias Hepáticas / Superóxidos / Hepatócitos / Citosol / Proteínas Mitocondriais / Proteínas Quinases JNK Ativadas por Mitógeno / Doença Hepática Induzida por Substâncias e Drogas / Overdose de Drogas / Acetaminofen Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mitocôndrias Hepáticas / Superóxidos / Hepatócitos / Citosol / Proteínas Mitocondriais / Proteínas Quinases JNK Ativadas por Mitógeno / Doença Hepática Induzida por Substâncias e Drogas / Overdose de Drogas / Acetaminofen Idioma: En Ano de publicação: 2021 Tipo de documento: Article