Novel Targeted Photosensitizer as an Immunomodulator for Highly Efficient Therapy of T-Cell Acute Lymphoblastic Leukemia.

Yuan, Gankun; Yao, Mengyu; Lv, Huihui; Jia, Xiao; Chen, Juanjuan; Xue, Jinping

Yuan, Gankun; Yao, Mengyu; Lv, Huihui; Jia, Xiao; Chen, Juanjuan; Xue, Jinping.

Afiliação

Yuan G; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.
Yao M; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.
Lv H; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.
Jia X; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.
Chen J; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.
Xue J; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, University Town, Fuzhou 350116, Fujian, P. R. China.

J Med Chem ; 63(24): 15655-15667, 2020 12 24.

Article em En | MEDLINE | ID: mdl-33300796

Assuntos

Fatores Imunológicos/química; Fármacos Fotossensibilizantes/química; Animais; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Dasatinibe/química; Dasatinibe/farmacologia; Dasatinibe/uso terapêutico; Feminino; Humanos; Fatores Imunológicos/farmacologia; Fatores Imunológicos/uso terapêutico; Indóis/química; Indóis/farmacologia; Indóis/uso terapêutico; Isoindóis; Células Matadoras Naturais/citologia; Células Matadoras Naturais/imunologia; Células Matadoras Naturais/metabolismo; Luz; Proteína Tirosina Quinase p56(lck) Linfócito-Específica/genética; Proteína Tirosina Quinase p56(lck) Linfócito-Específica/metabolismo; Camundongos; Camundongos Nus; Compostos Organometálicos/química; Compostos Organometálicos/farmacologia; Compostos Organometálicos/uso terapêutico; Fotoquimioterapia; Fármacos Fotossensibilizantes/farmacologia; Fármacos Fotossensibilizantes/uso terapêutico; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia; Espécies Reativas de Oxigênio/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Compostos de Zinco

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Fotossensibilizantes / Fatores Imunológicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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