Successful expansion of Mycobacterium tuberculosis Latin American and Mediterranean sublineage (L4.3/LAM) in Tunisia mainly driven by a single, long-established clonal complex.

Skhairia, Mohamed Amine; Dekhil, Naira; Mhenni, Besma; Fradj, Saloua Ben; Mardassi, Helmi

Skhairia, Mohamed Amine; Dekhil, Naira; Mhenni, Besma; Fradj, Saloua Ben; Mardassi, Helmi.

Afiliação

Skhairia MA; Unit of Typing and Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.
Dekhil N; Unit of Typing and Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.
Mhenni B; Unit of Typing and Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.
Fradj SB; Unit of Typing and Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.
Mardassi H; Unit of Typing and Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia. Electronic address: helmi.merdassi@pasteur.rns.tn.

Int J Infect Dis ; 103: 220-225, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33307222

Assuntos

Mycobacterium tuberculosis/genética; Polimorfismo de Nucleotídeo Único/genética; Tuberculose/microbiologia; Teorema de Bayes; Loci Gênicos/genética; Genética Populacional; Genômica; Genótipo; Humanos; América Latina; Região do Mediterrâneo; Filogenia; Tuberculose/epidemiologia; Tunísia/epidemiologia; Sequenciamento Completo do Genoma

Palavras-chave

Clonal complex; Evolution; Genotyping; L4.3/LAM; Mycobacterium tuberculosis; Whole-genome sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Polimorfismo de Nucleotídeo Único / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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