Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-&#954;B, a link between inflammation and mineralization.

Éva Sikura, Katalin; Combi, Zsolt; Potor, László; Szerafin, Tamás; Hendrik, Zoltán; Méhes, Gábor; Gergely, Péter; Whiteman, Matthew; Beke, Lívia; Fürtös, Ibolya; Balla, György; Balla, József

Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization.

Éva Sikura, Katalin; Combi, Zsolt; Potor, László; Szerafin, Tamás; Hendrik, Zoltán; Méhes, Gábor; Gergely, Péter; Whiteman, Matthew; Beke, Lívia; Fürtös, Ibolya; Balla, György; Balla, József.

Afiliação

Éva Sikura K; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
Combi Z; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.
Potor L; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
Szerafin T; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.
Hendrik Z; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
Méhes G; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.
Gergely P; Department of Cardiac Surgery, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
Whiteman M; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
Beke L; Department of Pathology, University of Debrecen, Faculty of Medicine, 4012 Debrecen, Hungary.
Fürtös I; Department of Pathology, University of Debrecen, Faculty of Medicine, 4012 Debrecen, Hungary.
Balla G; Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Balla J; University of Exeter Medical School, St. Luke's Campus, Magdalen Road, Exeter EX1 2LU, UK.

J Adv Res ; 27: 165-176, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33318875

Palavras-chave

AP72; AP72, 4-methoxyphenyl piperidinylphosphinodithioc acid; AS, stenotic aortic valve with calcification; Aortic valve; ApoE-/-, apolipoprotein E-deficient mice; Apolipoprotein E knockout mice; CAVD; CAVD, calcific aortic valve disease; CBS, Cystathionine beta-synthase; CSE, Cystathionine gamma-lyase; H2S; HAV, healthy aortic valve from suicide patients; IL-1ß, interleukin-1ß; Inflammation; NF-κB, nuclear factor-κB; STED, Stimulated Emission Depletion Nanoscopy; TNF-α, tumor necrosis factor α; VIC, valvular interstitial cells; cVIC, control healthy valve interstitial cells; mHAV, healthy mouse aortic valve; mVIC, mouse valvular interstitial cells

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article