Cost-effectiveness of second-line nivolumab for platinum-treated advanced non-small-cell lung cancer.
J Comp Eff Res
; 9(18): 1301-1309, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33325265
ABSTRACT
Aim:
To analyze the economic impact of nivolumab and chemotherapy in patients with non-small-cell lung cancer (NSCLC) who developed disease progression after platinum-containing dual-drug chemotherapy. Materials &methods:
The partitioned survival model was used to analyze the cost-utility of two NSCLC treatments by nivolumab and docetaxel. The clinical data resulted from the Phase III clinical trial. The cost parameters were derived from our previous studies, and the utility parameters were derived from the literature.Results:
The quality-adjusted life-years of nivolumab and docetaxel were 0.778 and 0.336. The lifetime direct medical expenses of nivolumab and docetaxel were US$44,707.17 and US$12,826.72. The incremental cost-effectiveness ratio was $72,127.71/quality-adjusted life-year.Conclusion:
The combination of chemotherapy, nivolumab is not a cost-effective choice in the second-line treatment of NSCLC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Platina
/
Carcinoma Pulmonar de Células não Pequenas
/
Nivolumabe
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Neoplasias Pulmonares
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article