DeepRetina: Layer Segmentation of Retina in OCT Images Using Deep Learning.

ABSTRACT

Purpose: To automate the segmentation of retinal layers, we propose DeepRetina, a method based on deep neural networks. Methods: DeepRetina uses the improved Xception65 to extract and learn the characteristics of retinal layers. The Xception65-extracted feature maps are inputted to an atrous spatial pyramid pooling module to obtain multiscale feature information. This information is then recovered to capture clearer retinal layer boundaries in the encoder-decoder module, thus completing retinal layer auto-segmentation of the retinal optical coherence tomography (OCT) images. Results: We validated this method using a retinal OCT image database containing 280 volumes (40 B-scans per volume) to demonstrate its effectiveness. The results showed that the method exhibits excellent performance in terms of the mean intersection over union and sensitivity (Se), which are as high as 90.41 and 92.15%, respectively. The intersection over union and Se values of the nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, outer limiting membrane, photoreceptor inner segment, photoreceptor outer segment, and pigment epithelium layer were found to be above 88%. Conclusions: DeepRetina can automate the segmentation of retinal layers and has great potential for the early diagnosis of fundus retinal diseases. In addition, our approach will provide a segmentation model framework for other types of tissues and cells in clinical practice. Translational Relevance Automating the segmentation of retinal layers can help effectively diagnose and monitor clinical retinal diseases. In addition, it requires only a small amount of manual segmentation, significantly improving work efficiency.