Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells.

Hatamie, Amir; Ren, Lin; Dou, Haiqiang; Gandasi, Nikhil R; Rorsman, Patrik; Ewing, Andrew

Hatamie, Amir; Ren, Lin; Dou, Haiqiang; Gandasi, Nikhil R; Rorsman, Patrik; Ewing, Andrew.

Afiliação

Hatamie A; Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, 41296, Gothenburg, Sweden.
Ren L; Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, 41296, Gothenburg, Sweden.
Dou H; Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11-13, 41390, Gothenburg, Sweden.
Gandasi NR; Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11-13, 41390, Gothenburg, Sweden.
Rorsman P; Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11-13, 41390, Gothenburg, Sweden.
Ewing A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK.

Angew Chem Int Ed Engl ; 60(14): 7593-7596, 2021 03 29.

Article em En | MEDLINE | ID: mdl-33340209

Assuntos

Exocitose/fisiologia; Células Secretoras de Insulina/metabolismo; Insulina/análise; Serotonina/química; Animais; Glicemia/metabolismo; Citoplasma/metabolismo; Citoplasma/ultraestrutura; Diabetes Mellitus Tipo 2/metabolismo; Técnicas Eletroquímicas; Humanos; Camundongos

Palavras-chave

beta cells; electrochemical analysis; exocytosis; nanoelectrodes; partial release

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serotonina / Células Secretoras de Insulina / Exocitose / Insulina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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