[GWAS-based polygenic risk scores for depression with clinical validation: methods and study design in the Russian population]. / Poligennye shkaly riska razvitiya depressii na osnove GWAS s klinicheskoi validatsiei: metodologiya i dizain issledovaniya v rossiiskoi populyatsii.
Zh Nevrol Psikhiatr Im S S Korsakova
; 120(11): 131-140, 2020.
Article
em Ru
| MEDLINE
| ID: mdl-33340308
ABSTRACT
Depression is one of the leading causes of decreased quality of life and social functioning of patients. In the context of preventive medicine, the prevention of depression becomes a priority. To achieve the goals of prevention, it is necessary to identify specific population risk groups - individuals with a high genetic risk of depression. The paper describes the project aimed at developing a genetic test system based on polygenic risk scores (PRS) for depression, considering the multi-ethnicity and multicultural diversity of the Russian population. As a result of the study, data on the genetic architecture of depression (GWAS) and PRS for depression will be obtained for the first time. The emergence of a genetic test system developed in the study of the Russian population and in the conditions of a constant decrease in the cost of genetic research will allow an effective transition to preventive medicine in the area of mental health.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressão
/
Estudo de Associação Genômica Ampla
Idioma:
Ru
Ano de publicação:
2020
Tipo de documento:
Article