Ferritin as a Platform for Creating Antiviral Mosaic Nanocages: Prospects for Treating COVID-19.
Chembiochem
; 22(8): 1371-1378, 2021 04 16.
Article
em En
| MEDLINE
| ID: mdl-33350032
ABSTRACT
Infectious diseases are a continues threat to human health and the economy worldwide. The latest example is the global pandemic of COVID-19 caused by SARS-CoV-2. Antibody therapy and vaccines are promising approaches to treat the disease; however, they have bottlenecks they might have low efficacy or narrow breadth due to the continuous emergence of new strains of the virus or antibodies could cause antibody-dependent enhancement (ADE) of infection. To address these bottlenecks, I propose the use of 24-meric ferritin for the synthesis of mosaic nanocages to deliver a cocktail of antibodies or nanobodies alone or in combination with another therapeutic, like a nucleotide analogue, to mimic the viral entry process and deceive the virus, or to develop mosaic vaccines. I argue that available data showing the effectiveness of ferritin-antibody conjugates in targeting specific cells and ferritin-haemagglutinin nanocages in developing influenza vaccines strongly support my proposals.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Nanoestruturas
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Ferritinas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article