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Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.
Estrada-Bernal, Adriana; Le, Anh T; Doak, Andrea E; Tirunagaru, Vijaya G; Silva, Shevan; Bull, Matthew R; Smaill, Jeff B; Patterson, Adam V; Kim, Chul; Liu, Stephen V; Doebele, Robert C.
Afiliação
  • Estrada-Bernal A; Department of Medicine, Division of Medical Oncology, University of Colorado, Aurora, Colorado.
  • Le AT; Department of Medicine, Division of Medical Oncology, University of Colorado, Aurora, Colorado.
  • Doak AE; Department of Medicine, Division of Medical Oncology, University of Colorado, Aurora, Colorado.
  • Tirunagaru VG; Rain Therapeutics, Newark, California.
  • Silva S; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
  • Bull MR; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
  • Smaill JB; Maurice Wilkins Centre for Molecular Biodiscovery, c/o The University of Auckland, Auckland, New Zealand.
  • Patterson AV; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
  • Kim C; Maurice Wilkins Centre for Molecular Biodiscovery, c/o The University of Auckland, Auckland, New Zealand.
  • Liu SV; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
  • Doebele RC; Maurice Wilkins Centre for Molecular Biodiscovery, c/o The University of Auckland, Auckland, New Zealand.
Clin Cancer Res ; 27(5): 1463-1475, 2021 03 01.
Article em En | MEDLINE | ID: mdl-33355298
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Carcinoma Pulmonar de Células não Pequenas / Receptor ErbB-2 / Inibidores de Proteínas Quinases / Adenocarcinoma de Pulmão / Hipóxia Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Carcinoma Pulmonar de Células não Pequenas / Receptor ErbB-2 / Inibidores de Proteínas Quinases / Adenocarcinoma de Pulmão / Hipóxia Idioma: En Ano de publicação: 2021 Tipo de documento: Article