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IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.
Singh, Kumar Sachin; Sharma, Rishabh; Reddy, Poli Adi Narayana; Vonteddu, Prashanthi; Good, Madeline; Sundarrajan, Anjana; Choi, Hyeree; Muthumani, Kar; Kossenkov, Andrew; Goldman, Aaron R; Tang, Hsin-Yao; Totrov, Maxim; Cassel, Joel; Murphy, Maureen E; Somasundaram, Rajasekharan; Herlyn, Meenhard; Salvino, Joseph M; Dotiwala, Farokh.
Afiliação
  • Singh KS; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Sharma R; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Reddy PAN; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
  • Vonteddu P; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Good M; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
  • Sundarrajan A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Choi H; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Muthumani K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
  • Kossenkov A; Bioinformatics Facility, The Wistar Institute, Philadelphia, PA, USA.
  • Goldman AR; Proteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA.
  • Tang HY; Proteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA.
  • Totrov M; Molsoft, San Diego, CA, USA.
  • Cassel J; Molecular Screening and Protein Expression Facility, The Wistar Institute, Philadelphia, PA, USA.
  • Murphy ME; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
  • Somasundaram R; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
  • Herlyn M; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
  • Salvino JM; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA. jsalvino@wistar.org.
  • Dotiwala F; Molecular Screening and Protein Expression Facility, The Wistar Institute, Philadelphia, PA, USA. jsalvino@wistar.org.
Nature ; 589(7843): 597-602, 2021 01.
Article em En | MEDLINE | ID: mdl-33361818
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredutases / Ativação Linfocitária / Linfócitos T Citotóxicos / Desenho de Fármacos / Proteínas de Escherichia coli / Inibidores Enzimáticos / Viabilidade Microbiana / Bactérias Gram-Negativas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredutases / Ativação Linfocitária / Linfócitos T Citotóxicos / Desenho de Fármacos / Proteínas de Escherichia coli / Inibidores Enzimáticos / Viabilidade Microbiana / Bactérias Gram-Negativas Idioma: En Ano de publicação: 2021 Tipo de documento: Article