Design and Applications of a SO2 Surrogate in Palladium-Catalyzed Direct Aminosulfonylation between Aryl Iodides and Amines.
Angew Chem Int Ed Engl
; 60(13): 7353-7359, 2021 03 22.
Article
em En
| MEDLINE
| ID: mdl-33368936
ABSTRACT
A new SO2 surrogate is reported that is cheap, bench-stable, and can be accessed in just two steps from bulk chemicals. Essentially complete SO2 release is achieved in 5â
minutes. Eight established sulfonylation reactions proceeded smoothly by exâ
situ formation of SO2 by utilizing a two-chamber system in combination with the SO2 surrogate. Furthermore, we report the first direct aminosulfonylation between aryl iodides and amines. Broad functional group tolerance is demonstrated, and the method is applicable to pharmaceutically relevant substrates, including heterocyclic substrates.
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MEDLINE
Idioma:
En
Ano de publicação:
2021
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Article