Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome.

Li, Jun; Qi, Zhijiang; Li, Dongxiao; Huang, Xiao; Qi, Boyang; Feng, Jiali; Qu, Jianyu; Wang, Xiaozhi

Li, Jun; Qi, Zhijiang; Li, Dongxiao; Huang, Xiao; Qi, Boyang; Feng, Jiali; Qu, Jianyu; Wang, Xiaozhi.

Afiliação

Li J; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Deparetment of Pulmonary and Critical Care Medicine, Yantai Affiliated Hospital of Binzhou Medical University, YanTai, Shandong, 264100, China.
Qi Z; Deparetment of Pulmonary and Critical Care Medicine, Yantai Affiliated Hospital of Binzhou Medical University, YanTai, Shandong, 264100, China.
Li D; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Huang X; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Qi B; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Feng J; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Qu J; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Wang X; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Department of Pulmonary and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China. Electronic address: hxicuwxz@163.com.

Biomed Pharmacother ; 133: 111026, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33378942

Assuntos

Células Epiteliais Alveolares/patologia; Barreira Alveolocapilar/patologia; Glicocálix/patologia; Síndrome do Desconforto Respiratório/patologia; Junções Íntimas/patologia; Células A549; Células Epiteliais Alveolares/metabolismo; Animais; Barreira Alveolocapilar/metabolismo; Líquido da Lavagem Broncoalveolar/química; Modelos Animais de Doenças; Glicocálix/metabolismo; Heparitina Sulfato/metabolismo; Humanos; Masculino; Camundongos Endogâmicos C57BL; Permeabilidade; Síndrome do Desconforto Respiratório/metabolismo; Junções Íntimas/metabolismo; Proteína da Zônula de Oclusão-1/genética; Proteína da Zônula de Oclusão-1/metabolismo

Palavras-chave

Acute respiratory distress syndrome; Alveolar barrier; Alveolar epithelial glycocalyx; Heparanase; Tight junction proteins

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Barreira Alveolocapilar / Junções Íntimas / Glicocálix / Células Epiteliais Alveolares Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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