Optimized self-immolative near-infrared probe based on hemicyanine for highly specific monitoring thiophenols in living systems.
Talanta
; 224: 121785, 2021 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-33379014
ABSTRACT
In this paper, utilizing the same recognition group dinitrophenyl and hydroxyl functional NIR fluorophore hemicyanine, directly-linked probe CyNO2 and self-immolative probe CyBNO2 were developed for evaluation of sensing PhSH. Though CyNO2 was easily synthesized and sensitive to mercapto, the probe CyBNO2 showed higher selectivity, broader linear range from 1.0 × 10-7 to 7.0 × 10-6 M with lower detection limit of 22 nM for PhSH. Moreover, CyBNO2 was successfully applied for monitoring PhSH in living cells and in vivo, indicating the great potential of self-immolative probes.
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MEDLINE
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Fenóis
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Compostos de Sulfidrila
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En
Ano de publicação:
2021
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Article