Functional evidence of low-pressure cardiopulmonary baroreceptor reinnervation 1 year after heart transplantation.
Eur J Appl Physiol
; 121(3): 915-927, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33389144
ABSTRACT
PURPOSE:
Heart transplantation (HTx) implies denervation of afferent neural connections. Reinnervation of low-pressure cardiopulmonary baroreceptors might impact the development and treatment of hypertension, but little is known of its occurrence. The present prospective study investigated possible afferent reinnervation of low-pressure cardiopulmonary baroreceptors during the first year after heart transplantation.METHODS:
A total of 50 heart transplant recipients (HTxRs) were included and were evaluated 7-12 weeks after transplant surgery, with follow-up 6 and 12 months later. In addition, a reference group of 50 healthy control subjects was examined once. Continuous, non-invasive recordings of cardiovascular variables were carried out at supine rest, during 15 min of 20° head-up tilt, during Valsalva maneuver and during 1 min of 30% maximal voluntary handgrip. In addition, routine clinical data including invasive measurements were used in the analyses.RESULTS:
During the first year after HTx, the heart rate (HR) response to 20° head-up tilt partly normalized, a negative relationship between resting mean right atrial pressure and HR tilt response developed, low-frequency variability of the RR interval and systolic blood pressure at supine rest increased, and the total peripheral resistance response to Valsalva maneuver became stronger.CONCLUSION:
Functional assessments suggest that afferent reinnervation of low-pressure cardiopulmonary receptors occurs during the first year after heart transplantation, partially restoring reflex-mediated responses to altered cardiac filling.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pressorreceptores
/
Sistema Cardiovascular
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Transplante de Coração
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Força da Mão
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Frequência Cardíaca
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Pulmão
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article