Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures.
Clin Kidney J
; 13(6): 1101-1104, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33391755
ABSTRACT
BACKGROUND:
The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).METHODS:
Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.RESULTS:
All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining.CONCLUSIONS:
The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article