Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function.

Zhou, Liang; Yu, Wenjun; Jayabalan, David S; Niesvizky, Ruben; Jaffrey, Samie R; Huang, Xiangao; Xu, Guoqiang.

Afiliação

Zhou L; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Yu W; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Jayabalan DS; Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Niesvizky R; Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Jaffrey SR; Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States.
Huang X; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States.
Xu G; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.

Front Cell Dev Biol ; 8: 605989, 2020.

Article em En | MEDLINE | ID: mdl-33392195