Serum Exosomal microRNA-27-3p Aggravates Cerebral Injury and Inflammation in Patients with Acute Cerebral Infarction by Targeting PPARÎ³.

Ye, Zhinan; Hu, Jingchun; Xu, Hao; Sun, Bin; Jin, Yong; Zhang, Yaping; Zhang, Jianli

Ye, Zhinan; Hu, Jingchun; Xu, Hao; Sun, Bin; Jin, Yong; Zhang, Yaping; Zhang, Jianli.

Afiliação

Ye Z; Department of Neurology, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, 318000, Zhejiang Province, China.
Hu J; Department of Anesthesiology, Lishui Municipal Central Hospital, Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Wenzhou, 323000, Zhejiang Province, China.
Xu H; Department of Neurology, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, 318000, Zhejiang Province, China.
Sun B; Department of Neurology, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, 318000, Zhejiang Province, China.
Jin Y; Department of Neurosurgery, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, 318000, Zhejiang Province, China.
Zhang Y; Department of Neurology, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, 318000, Zhejiang Province, China.
Zhang J; Department of Neurology, Lishui Municipal Central Hospital, Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, No.289 Kuocang Road, Liandu District of Lishui City, Wenzhou, 323000, Zhejiang Province, China. zhangjianli0123@163.com.

Inflammation ; 44(3): 1035-1048, 2021 Jun.

Article em En | MEDLINE | ID: mdl-33394189

Assuntos

Encéfalo/metabolismo; Exossomos/transplante; Infarto da Artéria Cerebral Média/metabolismo; MicroRNAs/metabolismo; Microglia/metabolismo; PPAR gama/metabolismo; Idoso; Animais; Comportamento Animal; Encéfalo/patologia; Estudos de Casos e Controles; Linhagem Celular; Infarto Cerebral/sangue; Infarto Cerebral/diagnóstico por imagem; Infarto Cerebral/genética; Bases de Dados Genéticas; Modelos Animais de Doenças; Exossomos/genética; Exossomos/metabolismo; Feminino; Humanos; Infarto da Artéria Cerebral Média/sangue; Infarto da Artéria Cerebral Média/genética; Infarto da Artéria Cerebral Média/patologia; Mediadores da Inflamação/metabolismo; Masculino; MicroRNAs/sangue; MicroRNAs/genética; Microglia/patologia; Pessoa de Meia-Idade; PPAR gama/genética; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

Acute cerebral infarction; Inflammation; Microglia; Middle cerebral artery occlusion; PPARÎ³; Serum exosomes; microRNA-27-3p

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Microglia / Infarto da Artéria Cerebral Média / MicroRNAs / PPAR gama / Exossomos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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