Aptamer-Functionalized Micro- and Nanocarriers for Controlled Release.
ACS Appl Mater Interfaces
; 13(8): 9520-9541, 2021 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-33395247
ABSTRACT
Sequence-specific nucleic acids recognizing low-molecular-weight ligands or macromolecules (aptamers) have found growing interest for biomedical applications. The present review article summarizes recent applications of aptamers as stimuli-responsive gating units of drug (or dye)-loaded nano- or microcarriers for controlled and targeted drug release. In the presence of cellular biomarkers, the nano-/microcarriers are unlocked by forming aptamer-ligand complexes. Different aptamer-functinalized nano-/microcarriers are presented, including inorganic nanomaterials, metal-organic framework nanoparticles, and soft materials. The chemistries associated with the preparation of the carriers and the mechanisms to unlock the carriers are discussed. Stimuli-responsive gated drug-loaded micro-/nanocarriers hold great promise as functional sense-and-treat materials for the targeted and selective release of drugs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preparações de Ação Retardada
/
Aptâmeros de Nucleotídeos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article