Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species.
Mol Med Rep
; 23(3)2021 03.
Article
em En
| MEDLINE
| ID: mdl-33398363
ABSTRACT
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancerrelated mortality worldwide according to Global Cancer Statistics 2018. Resveratrol (RSV) is a phenolic compound that possesses anticancer functions against various types of cancer, including breast and gastric cancer. However, the functions and mechanism underlying RSV in CRC are not completely understood. The present study aimed to investigate the anticancer effects and mechanism underlying RSV in CRC cells by conducting Cell Counting Kit8, apoptosis, reactive oxygen species (ROS) and western blotting assays. The results suggested that RSV dosedependently inhibited CRC cell viability, and increased cell apoptosis and ROS levels compared with the control group. The protein expression levels of Bax, cytochrome c, cleaved caspase9 and cleaved caspase3 were upregulated, whereas Bcl2 expression levels were downregulated in RSVtreated CRC cells compared with control cells. The results indicated that RSV might activate the mitochondrial apoptotic pathway by increasing ROS release. The present study suggested that RSV possessed antitumour activity against CRC by modulating an ROSmediated mitochondrial apoptotic pathway.
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MEDLINE
Assunto principal:
Neoplasias Colorretais
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Transdução de Sinais
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Espécies Reativas de Oxigênio
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Apoptose
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Resveratrol
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Mitocôndrias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article