Alteration of water absorption in the THz region traces the onset of fibrillation in proteins.
Chem Commun (Camb)
; 57(8): 998-1001, 2021 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-33399590
ABSTRACT
Using terahertz spectroscopy, we established the alteration of the collective hydration of water during the fibrillation process (native â intermediate â fibril) of a model protein bovine serum albumin. This label-free study concludes that water dynamics change systematically with protein conformational changes as it experiences a hydrophobic environment during the initial protein unfolding process, followed by the release of bound water during oligomerization and finally the hydrophobic interior of the fibril.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Soroalbumina Bovina
/
Água
/
Espectroscopia Terahertz
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article