Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.

Leinweber, Jonas; Mizurini, Daniella M; Francischetti, Ivo M B; Fleischer, Michael; Hermann, Dirk M; Kleinschnitz, Christoph; Langhauser, Friederike

Leinweber, Jonas; Mizurini, Daniella M; Francischetti, Ivo M B; Fleischer, Michael; Hermann, Dirk M; Kleinschnitz, Christoph; Langhauser, Friederike.

Afiliação

Leinweber J; Department of Neurology of University Hospital Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany.
Mizurini DM; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Francischetti IMB; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fleischer M; Department of Neurology of University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany.
Hermann DM; Department of Neurology of University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany.
Kleinschnitz C; Department of Neurology of University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany.
Langhauser F; Department of Neurology of University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany. Electronic address: Friederike.Langhauser@uk-essen.de.

Brain Behav Immun ; 93: 288-298, 2021 03.

Article em En | MEDLINE | ID: mdl-33401017

Assuntos

Isquemia Encefálica; Proteínas de Insetos/farmacologia; AVC Isquêmico; Elastase Pancreática/antagonistas & inibidores; Proteínas e Peptídeos Salivares/farmacologia; Trombose; Animais; Barreira Hematoencefálica; Modelos Animais de Doenças; Infarto da Artéria Cerebral Média/complicações; Infarto da Artéria Cerebral Média/tratamento farmacológico; Inflamação/tratamento farmacológico; AVC Isquêmico/tratamento farmacológico; Masculino; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Agaphelin; Antithrombotic; Apoptosis; Bleeding complication; Blood-brainbarrier; Experimental stroke; Inflammation; Neutrophil elastase inhibitor; Thromboinflammation; Thrombosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas e Peptídeos Salivares / Trombose / Elastase Pancreática / Isquemia Encefálica / Proteínas de Insetos / AVC Isquêmico Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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