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CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation.
Kitai, Yuichi; Ishiura, Marie; Saitoh, Kodai; Matsumoto, Naoki; Owashi, Kimiya; Yamada, Shunsuke; Muromoto, Ryuta; Kashiwakura, Jun-Ichi; Oritani, Kenji; Matsuda, Tadashi.
Afiliação
  • Kitai Y; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Ishiura M; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Saitoh K; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Matsumoto N; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Owashi K; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Yamada S; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Muromoto R; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Kashiwakura JI; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
  • Oritani K; Department of Hematology, International University of Health and Welfare, Narita, Chiba, Japan.
  • Matsuda T; Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-Ku, Sapporo, Hokkaido, Japan.
Int Immunol ; 33(5): 273-280, 2021 04 22.
Article em En | MEDLINE | ID: mdl-33406263
ABSTRACT
CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking promotes engulfment of cancer cells by macrophages, it is important to clarify the mechanism of CD47 signaling in order to develop treatments for diseases involving CD47-overexpressing cancer cells, including breast cancer and lymphoma. Here, we show that CD47 plays an essential role in T-cell lymphoma metastasis by up-regulating basal RhoA activity independent of its anti-phagocytic function. CD47 interacts with AKAP13, a RhoA-specific guanine nucleotide exchange factor (GEF), and facilitates AKAP13-mediated RhoA activation. Our study shows that CD47 has a novel function on the AKAP13-RhoA axis and suggests that CD47-AKAP13 interaction would be a novel target for T-cell lymphoma treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Menor / Linfoma de Células T / Proteínas Proto-Oncogênicas / Proteína rhoA de Ligação ao GTP / Antígeno CD47 / Proteínas de Ancoragem à Quinase A / Metástase Neoplásica Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Menor / Linfoma de Células T / Proteínas Proto-Oncogênicas / Proteína rhoA de Ligação ao GTP / Antígeno CD47 / Proteínas de Ancoragem à Quinase A / Metástase Neoplásica Idioma: En Ano de publicação: 2021 Tipo de documento: Article