Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission.

Hu, Hui-Fang; Xu, Wen Wen; Li, Yang-Jia; He, Yan; Zhang, Wei-Xia; Liao, Long; Zhang, Qi-Hua; Han, Lei; Yin, Xing-Feng; Zhao, Xiao-Xu; Pan, Yun-Long; Li, Bin; He, Qing-Yu

Hu, Hui-Fang; Xu, Wen Wen; Li, Yang-Jia; He, Yan; Zhang, Wei-Xia; Liao, Long; Zhang, Qi-Hua; Han, Lei; Yin, Xing-Feng; Zhao, Xiao-Xu; Pan, Yun-Long; Li, Bin; He, Qing-Yu.

Afiliação

Hu HF; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
Xu WW; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Li YJ; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
He Y; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Zhang WX; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
Liao L; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
Zhang QH; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
Han L; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Yin XF; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
Zhao XX; MOE Key Laboratory of Tumor Molecular Biology and Department of General Surgery, First-Affiliated Hospital, Jinan University, Guangzhou, China.
Pan YL; MOE Key Laboratory of Tumor Molecular Biology and Department of General Surgery, First-Affiliated Hospital, Jinan University, Guangzhou, China.
Li B; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.
He QY; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, China.

Theranostics ; 11(4): 1828-1844, 2021.

Article em En | MEDLINE | ID: mdl-33408784

Assuntos

Fator 1 de Ribosilação do ADP/metabolismo; Neoplasias do Colo/tratamento farmacológico; Dinaminas/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Dinâmica Mitocondrial/efeitos dos fármacos; Ftalazinas/farmacologia; Proteínas Ativadoras de ras GTPase/metabolismo; Fator 1 de Ribosilação do ADP/genética; Animais; Antialérgicos/farmacologia; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Proliferação de Células; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Dinaminas/genética; MAP Quinases Reguladas por Sinal Extracelular/genética; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Prognóstico; Taxa de Sobrevida; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas Ativadoras de ras GTPase/genética

Palavras-chave

ARF1; azelastine; colorectal cancer; drug repurposing; mitochondrial fission

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Regulação Neoplásica da Expressão Gênica / Neoplasias do Colo / Fator 1 de Ribosilação do ADP / Proteínas Ativadoras de ras GTPase / Dinaminas / MAP Quinases Reguladas por Sinal Extracelular / Dinâmica Mitocondrial Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google