Design of a Novel Nucleus-Targeted NLS-KALA-SA Nanocarrier to Delivery Poorly Water-Soluble Anti-Tumor Drug for Lung Cancer Treatment.

Yan, Chengyun; Shi, Weiguo; Gu, Jiwei; Lee, Robert J; Zhang, Yuan

Yan, Chengyun; Shi, Weiguo; Gu, Jiwei; Lee, Robert J; Zhang, Yuan.

Afiliação

Yan C; College of Pharmacy, Guilin Medical University, Guilin 541004, China. Electronic address: hademan@126.com.
Shi W; College of Pharmacy, Jiamusi of University, Jiamusi 154000, China.
Gu J; First Affiliated Hospital of Jiamusi University, Jiamusi of University, Jiamusi 154000, China.
Lee RJ; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, 43210, USA.
Zhang Y; College of Pharmacy, Guilin Medical University, Guilin 541004, China.

J Pharm Sci ; 110(6): 2432-2441, 2021 06.

Article em En | MEDLINE | ID: mdl-33412169

Assuntos

Antineoplásicos; Neoplasias Pulmonares; Nanopartículas; Animais; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos; Liberação Controlada de Fármacos; Neoplasias Pulmonares/tratamento farmacológico; Camundongos; Sinais de Localização Nuclear/uso terapêutico; Paclitaxel/uso terapêutico; Ácidos Esteáricos; Distribuição Tecidual; Água

Palavras-chave

Antitumor activity; Kala peptide; Nanoparticles; Natural products; Nuclear localization signal; Nucleus-targeted

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias Pulmonares / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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