Location, function and role of stromal cellderived factors and possible implications in cancer (Review).
Int J Mol Med
; 47(2): 435-443, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33416125
ABSTRACT
Despite improvements in therapy and management, cancer represents and remains a major cause of mortality and morbidity worldwide. Although genetics serve an important role in tumorigenesis and tumour progression, the tumour microenvironment (TME) in solid tumours is also important and has been indicated to contribute to these processes. Stromal cellderived factors (SDFs) represent an important family within the TME. The family includes SDF1, SDF2, SDF2like 1 (SDF2L1), SDF3, SDF4 and SDF5. SDF1 has been demonstrated to act as a positive regulator in a number of types of tumour, such as oesophagogastric, pancreatic, lung, breast, colorectal and ovarian cancer, while the biology and functions of other members of the SDF family, including SDF2, SDF2L1, SDF4 and SDF5, in cancer are different, complex and controversial, and remain mainly unknown. Full identification and understanding of the SDFs across multiple types of cancer is required to elucidate their function and establish potential key targets in cancer.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos e Proteínas de Sinalização Intercelular
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Microambiente Tumoral
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Proteínas de Neoplasias
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Neoplasias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article