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Examining the relationship of immunotherapy and wound complications following flap reconstruction in patients with head and neck cancer.
Mays, Ashley C; Yarlagadda, Bharat; Achim, Virginie; Jackson, Ryan; Pipkorn, Patrik; Huang, Andrew T; Rajasekaran, Karthik; Sridharan, Shaum; Rosko, Andrew J; Orosco, Ryan K; Coughlin, Andrew M; Wax, Mark K; Shnayder, Yelizaveta; Spanos, William C; Farwell, Donald Gregory; McDaniel, Lee S; Hanasono, Matthew M.
Afiliação
  • Mays AC; Department of Otolaryngology, Louisiana State University, Baton Rouge, Louisiana, USA.
  • Yarlagadda B; Department of Otolaryngology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
  • Achim V; Department of Otolaryngology, University of Illinois at Chicago, Chicago, Illinois, USA.
  • Jackson R; Department of Otolaryngology, Washington University - St Louis, St Louis, Missouri, USA.
  • Pipkorn P; Department of Otolaryngology, Washington University - St Louis, St Louis, Missouri, USA.
  • Huang AT; Department of Otolaryngology, Baylor College of Medicine, Houston, Texas, USA.
  • Rajasekaran K; Department of Otolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Sridharan S; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Rosko AJ; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
  • Orosco RK; Department of Otolaryngology, University of California San Diego, San Diego, California, USA.
  • Coughlin AM; Department of Otolaryngology, Nebraska Methodist Health System, Omaha, Nebraska, USA.
  • Wax MK; Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon, USA.
  • Shnayder Y; Department of Otolaryngology, University of Kansas, Lawrence, Kansas, USA.
  • Spanos WC; Department of Otolaryngology, Sanford Health, Sioux Falls, South Dakota, USA.
  • Farwell DG; Department of Otolaryngology, University of California Davis, Sacramento, California, USA.
  • McDaniel LS; Louisiana State University Health Sciences Center School of Public Health, New Orleans, Louisiana, USA.
  • Hanasono MM; Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Head Neck ; 43(5): 1509-1520, 2021 05.
Article em En | MEDLINE | ID: mdl-33417293
BACKGROUND: Immunotherapy agents are used to treat advanced head and neck lesions. We aim to elucidate relationship between immunotherapy and surgical wound complications. METHODS: Retrospective multi-institutional case series evaluating patients undergoing ablative and flap reconstructive surgery and immunotherapy treatment. MAIN OUTCOME: wound complications. RESULTS: Eight-two (62%) patients received preoperative therapy, 89 (67%) postoperative, and 33 (25%) in both settings. Forty-one (31%) patients had recipient site complications, 12 (9%) had donor site. Nineteen (14%) had major recipient site complications, 22 (17%) had minor. There was no statistically significant difference in complications based on patient or tumor-specific variables. Preoperative therapy alone demonstrated increased major complications (odds ratio [OR] 3.7, p = 0.04), and trend to more donor site complications (OR 7.4, p = 0.06), however treatment in both preoperative and postoperative therapy was not. CONCLUSIONS: Preoperative immunotherapy may be associated with increased wound complications. Controlled studies are necessary to delineate this association and potential risks of therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Procedimentos de Cirurgia Plástica / Retalhos de Tecido Biológico / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Procedimentos de Cirurgia Plástica / Retalhos de Tecido Biológico / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2021 Tipo de documento: Article