Phototherapy With LED as an Effective Treatment for Chemotherapy-Induced Oral Mucositis in Hamsters.

Campos, Luana; Cotomacio, Claudia Carrara; Arana-Chavez, Victor Elias; Simões, Alyne

Campos, Luana; Cotomacio, Claudia Carrara; Arana-Chavez, Victor Elias; Simões, Alyne.

Afiliação

Campos L; Department of post-graduation, School of Dentistry, University of Santo Amaro, São Paulo 04829-300, Brazil.
Cotomacio CC; Department of Oral Medicine, Brazilian Institute of Cancer Control, São Paulo 03102-002, Brazil.
Arana-Chavez VE; Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil.
Simões A; Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil.

J Lasers Med Sci ; 11(4): 475-480, 2020.

Article em En | MEDLINE | ID: mdl-33425300

ABSTRACT

ABSTRACT

Introduction:

Oral mucositis (OM) has been considered one of the most feared collateral effects of oncological treatments. Some therapies have been used, such as light-emitting diode (LED), with promising results, but with no sufficient evidence in the literature.

Objective:

Our study aimed to evaluate, by clinical and histological analysis, the effect of LED on the treatment of chemotherapy-induced OM (CIOM) in an animal model.

Methods:

Twenty male hamsters were equally distributed to two groups control (C), which received anesthesia and CIOM induction; and LED (L), which received anesthesia, CIOM induction, and LED treatment (635 nm, 120 mW, 0.48 J). The clinical analysis was performed through two specific scales for OM analysis on days 5, 7 and 10 of the experiment. In addition, the injured area of all hamsters check pouch mucosa was removed and processed for histological analysis on the last experimental day.

Results:

After statistical analysis, group L showed less severity of OM when compared with the C group (P <0.05); beyond that, both healed completely on day 10.