Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.
Chembiochem
; 22(9): 1638-1645, 2021 05 04.
Article
em En
| MEDLINE
| ID: mdl-33427360
ABSTRACT
Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo- and deoxyxylo-nucleic acids (XyNA and dXyNA), containing 3' epimers of riboses and deoxyriboses, are considered to be potential candidates for an orthogonal system. In this study, thermal and spectroscopic analyses show that XyNA and dXyNA form stable hairpins. The dXyNA hairpin structure determined by NMR spectroscopy contains a flexible loop that locks the stem into a stable ladder-like duplex with marginal right-handed helicity. The reduced flexibility of the dXyNA duplex observed in the stem of the hairpin demonstrates that folding of dXyNA yields more stable structures described so far.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Xilose
/
Ácidos Nucleicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article