Epigenetic Regulation of Amyloid-beta Metabolism in Alzheimer's Disease.
Curr Med Sci
; 40(6): 1022-1030, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33428129
ABSTRACT
Senile plaques (SPs) are one of the pathological features of Alzheimer's disease (AD) and they are formed by the overproduction and aggregation of amyloid-beta (Aß) peptides derived from the abnormal cleavage of amyloid precursor protein (APP). Thus, understanding the regulatory mechanisms during Aß metabolism is of great importance to elucidate AD pathogenesis. Recent studies have shown that epigenetic modulation-including DNA methylation, non-coding RNA alterations, and histone modifications-is of great significance in regulating Aß metabolism. In this article, we review the aberrant epigenetic regulation of Aß metabolism.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
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Precursor de Proteína beta-Amiloide
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Epigênese Genética
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article