Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites.

Eisenhaber, Birgit; Sinha, Swati; Jadalanki, Chaitanya K; Shitov, Vladimir A; Tan, Qiao Wen; Sirota, Fernanda L; Eisenhaber, Frank

Eisenhaber, Birgit; Sinha, Swati; Jadalanki, Chaitanya K; Shitov, Vladimir A; Tan, Qiao Wen; Sirota, Fernanda L; Eisenhaber, Frank.

Afiliação

Eisenhaber B; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore. birgite@bii.a-star.edu.sg.
Sinha S; Genome Institute of Singapore (BII), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, 138672, Republic of Singapore. birgite@bii.a-star.edu.sg.
Jadalanki CK; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore.
Shitov VA; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore.
Tan QW; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore.
Sirota FL; Siberian State Medical University, Moskovskiy Trakt, 2, Tomsk, Tomsk Oblast, 634050, Russia.
Eisenhaber F; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore.

Biol Direct ; 16(1): 4, 2021 01 12.

Article em En | MEDLINE | ID: mdl-33436046

Assuntos

Proteínas de Transporte/genética; Proteínas de Membrana/genética; Sequência de Aminoácidos; Proteínas de Transporte/química; Proteínas de Transporte/metabolismo; Sequência Conservada; Humanos; Ligantes; Proteínas de Membrana/química; Proteínas de Membrana/metabolismo; Ligação Proteica; Alinhamento de Sequência

Palavras-chave

Dolichyl-phosphate-mannose-protein mannosyltransferase; GT-C glycosyl transferase; Membrane topology; O-mannosylation; PMT; TMTC1; TMTC2; TMTC3; TMTC4; Transmembrane region prediction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Proteínas de Membrana Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Proteínas de Membrana Idioma: En Ano de publicação: 2021 Tipo de documento: Article