Anti-tumor activity and immunogenicity of a succinoglycan riclin.
Carbohydr Polym
; 255: 117370, 2021 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-33436203
ABSTRACT
Natural polysaccharides have attracted considerable interests due to diverse biological activities. Succinoglycan is an extracellular polysaccharide produced by most Agrobacterium strains. Here, we confirmed riclin was a typical succinoglycan by NMR and methylation analysis, and investigated the antitumor effects of riclin in sarcoma 180 tumor-bearing mice. The results showed that riclin inhibited the tumor growth significantly as well as cyclophosphamide (CTX). While CTX caused serious damage to spleen structure, riclin increased the spleen index and promoted lymphocytes proliferation in peripheral blood, spleen and lymph nodes. Riclin decreased splenocytes apoptosis as evidenced by alterations of B-cell lymphoma-2 family proteins and Cleaved Caspase-3 protein. Moreover, 1H nuclear magnetic resonance (NMR)-based metabolomics analysis revealed that riclin partially altered the metabolic profiles of splenocytes. In conclusion, riclin is a succinoglycan that performed strong immunogenicity and suppressed sarcoma growth in mice. Succinoglycan riclin could be a potential antitumor agent for functional food and pharmaceutical purpose.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
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Sarcoma 180
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Linfócitos
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Regulação Neoplásica da Expressão Gênica
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Fatores Imunológicos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article