Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes.
Sci Rep
; 11(1): 1193, 2021 01 13.
Article
em En
| MEDLINE
| ID: mdl-33441948
ABSTRACT
Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a population-based survey of 196,219 UK Biobank men. We detected 12 (0.006%) men with mosaic chromosome X gains ≥ 2 Mb and found no evidence for mosaic chromosome X loss, a level of detection substantially lower than for autosomes or other sex chromosomes. The rarity of chromosome X mosaicism in males relative to females reflects the importance of chromosome X gene dosage for leukocyte function.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos X
/
Leucócitos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article