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Ruthenium arene complexes in the treatment of 3D models of head and neck squamous cell carcinomas.
Santi, Melissa; Mapanao, Ana Katrina; Biancalana, Lorenzo; Marchetti, Fabio; Voliani, Valerio.
Afiliação
  • Santi M; Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy; Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.
  • Mapanao AK; Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy; NEST-Scuola Normale Superiore, Piazza San Silvestro, 12-56126, Pisa, Italy.
  • Biancalana L; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.
  • Marchetti F; Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy. Electronic address: fabio.marchetti1974@unipi.it.
  • Voliani V; Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126, Pisa, Italy. Electronic address: valerio.voliani@iit.it.
Eur J Med Chem ; 212: 113143, 2021 Feb 15.
Article em En | MEDLINE | ID: mdl-33445155
Current chemotherapy for head and neck squamous cell carcinomas (HNSCCs) are based on cisplatin, which is usually associated to severe side effects. In general, the exploration for metal-based alternatives to cisplatin has resulted in the development of a series of ruthenium complexes that are able to produce a safe therapeutic action against some neoplasms, among which are lung and ovarian cancers. Here, we evaluate the efficacy of well defined, easily available and robust ruthenium(II) η6-arene compounds on 3D models of HNSCCs with or without human papillomavirus (HPV) infection and compare their effects to the state-of-the-art RAPTA-C, a promising ruthenium compound with known anti-cancer activity. One of the compounds induces a significant therapeutic action especially on HPV negative carcinoma. Besides viability and repopulation evaluations, we performed quantitative analysis of the internalized Ru compounds to further validate our findings and elucidate the possible mechanisms of action. These results show that Ru arene compounds represent a promising alternative for the treatment of HNSCCs and pave the way for the composition of innovative (co)therapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Carcinoma de Células Escamosas de Cabeça e Pescoço / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rutênio / Complexos de Coordenação / Carcinoma de Células Escamosas de Cabeça e Pescoço / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article