Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID19 (Review).
Int J Mol Med
; 47(3)2021 03.
Article
em En
| MEDLINE
| ID: mdl-33448317
ABSTRACT
Coronavirus disease 2019 (COVID19), caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2), was identified in December, 2019 in Wuhan, China. Since then, it has continued to spread rapidly in numerous countries, while the search for effective therapeutic options persists. Coronaviruses, including SARSCoV2, are known to suppress and evade the antiviral responses of the host organism mediated by interferon (IFN), a family of cytokines that plays an important role in antiviral defenses associated with innate immunity, and has been used therapeutically for chronic viral diseases and cancer. On the other hand, OncoTherad, a safe and effective immunotherapeutic agent in the treatment of nonmuscle invasive bladder cancer (NMIBC), increases IFN signaling and has been shown to be a promising therapeutic approach for COVID19 in a case report that described the rapid recovery of a 78yearold patient with NMIBC with comorbidities. The present review discusses the possible synergistic action of OncoTherad with vitamin D, zinc and glutamine, nutrients that have been shown to facilitate immune responses mediated by IFN signaling, as well as the potential of this combination as a therapeutic option for COVID19.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Fosfatos
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Vitamina D
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Zinco
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Glicoproteínas
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Interferons
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Tratamento Farmacológico da COVID-19
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Glutamina
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Fatores Imunológicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article